Diazinon.aac download

D Facts Diazinon ; U. Pesticide Products. Environmental Risk Assessment for Diazinon ; U. Timchalk, C. Organophosphate Pharmacokinetics. Handbook of Pesticide Toxicology , 2nd ed. Draft Toxicological Profile for Diazinon ; U. Reigert, J. Organophosphate Insecticides. Recognition and Management of Pesticide Poisonings , 5th ed. Lorgue, G. Peterson, M. Small Animal Toxicology , 2nd ed. Louis, ; pp , Cambell, A.

Gokcimen, A. Effects of diazinon at different doses on rat liver and pancreas tissues. Hopper, K. The recognition and treatment of the intermediate syndrome of organophosphate poisoning in a dog.

Care , 13 1 , Wagner, S. Diagnosis and Treatment of Organophosphate and Carbamate Intoxication. Thompson, C. Anticholinesterase Insecticides. Lotti, M. Organophosphate-Induced Delayed Polyneuropathy. Steenland, K. Public Health , 84 5 , Gokalp, O. The effect of diazinon on pancreatic damage and ameliorating role of vitamin E and vitamin C.

Environmental Protection Agency. Davis Jr. Cantor, K. Cancer Res. Daniels, J. Health Perspect. Slotkin, T. Whyatt, R. Kamrin, M. Roberts, T. Garfitt, S. Exposure to the organophosphate diazinon: data from a human volunteer study with oral and dermal doses.

Phillips, P. Temporal changes in surface-water insecticide concentrations after the phaseout of diazinon and chlorpyrifos. Moore, M. Water, Air, Soil Pollut. Diazinon exposure affects the nervous system of insects, people, and pets in the same basic way. However, the signs and symptoms from exposure may be different. Symptoms of diazinon exposure can happen within minutes or hours after the exposure. The signs and symptoms from a brief exposure can last several days or even weeks.

During this time, the body is replacing the chemicals needed for proper nervous system function. Diazinon exposure, whether from ingestion, skin contact, or inhalation can result in nervous system health effects.

These effects may include watery eyes, runny nose, drooling, loss of appetite, coughing, urination, diarrhea, stomach pain, and vomiting. Larger exposures can cause more severe signs and symptoms, including head and body tremors, muscle spasms or stiffness, muscle weakness or paralysis, rapid heart rate, difficulty breathing, seizures, convulsions, or coma.

Overall, diazinon is fairly low in toxicity when inhaled, ingested or when it gets on the skin, so minor exposures are not likely to cause severe symptoms. However, small exposures to diazinon can cause mild skin or eye irritation. Diazinon that gets inside the body by being eaten, breathed in, or getting it on the skin, is rapidly transported around the body in the blood to the organs. Once diazinon reaches the liver and kidneys, it can then be removed from the body by elimination in the urine and feces.

Most of the diazinon that enters the body is changed into other forms of the chemical, or metabolized, before the diazinon-based compound is removed from the body.

These diazinon-based compounds, known as metabolites, can be found in urine tests of exposed animals or people. After feeding laboratory animals high doses of diazinon for most of their lives, researchers found no evidence of cancer in the test animals. As such, the U. Environmental Protection Agency U. EPA has classified diazinon as a "not likely human carcinogen". Long-term exposure to diazinon in humans can change the normal level of chemicals in the nervous system without any noticeable effect.

Animal studies have also shown that long-term exposure to high doses of diazinon can lead to pancreatic damage as well as some reproductive or developmental effects in mothers or their offspring.

Animal studies have shown that young rats were more sensitive to the nervous system effects of diazinon than adult rats. In general, children may be more sensitive to pesticides. Also, children have diets and physical differences that may increase their exposure to diazinon.

Diazinon applied to soils can last for weeks or even months depending on the soil environment. Diazinon has the potential to dissolve in water, move through soils and contaminate groundwater. It was commonly found in drinking water sources before the phase-out of residential uses in Since the phase-out, diazinon has been detected in drinking water sources much less often. Bacteria, sunlight and other chemical reactions break down diazinon in the environment over time into other chemicals.

After diazinon has been applied, some of the diazinon can escape into the surrounding air, a process called volatilization. Diazinon can be taken up by plants and moved throughout. The amount of diazinon in or on plants will decrease over time as the diazinon is broken down by the plant and by the environment. Diazinon is very highly toxic to birds, bees and most other insects. Studies show that diazinon is moderately toxic to fish and amphibians, and is only slightly toxic to earthworms. NPIC provides objective, science-based answers to questions about pesticides.

Please cite as: Harper, B.